› › Structure analysis

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

X-ray diffraction
2.85Å resolution
PDB entry 2ojx coloured by chain, front view.
PDB entry 2ojx coloured by chain, side view.
PDB entry 2ojx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: M-phase inducer phosphatase 3 and Serine/threonine-protein kinase PLK1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 10924.65 Å2
Buried surface area: 617.93 Å2
Dissociation area: 308.97 Å2
Dissociation energy (ΔGdiss): -1.73 kcal/mol
Dissociation entropy (TΔSdiss): 6.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151704

Macromolecules

Serine/threonine-protein kinase PLK1
Chain: A
Length: 239 amino acids
Theoretical weight: 27.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53350 (Residues: 365-603; Coverage: 40%)
Gene names: PLK, PLK1
Pfam: POLO box duplicated region
InterPro:
CATH: POLO box domain
SCOP: Polo-box duplicated region
Serine/threonine-protein kinase PLK1 in PDB entry 2ojx, assembly 1, front view.
Serine/threonine-protein kinase PLK1 in PDB entry 2ojx, assembly 1, side view.
Serine/threonine-protein kinase PLK1 in PDB entry 2ojx, assembly 1, top view.
Molecule details ›

Search similar proteins

M-phase inducer phosphatase 3
Chain: E
Length: 9 amino acids
Theoretical weight: 917 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P30307 (Residues: 126-134; Coverage: 2%)
Gene name: CDC25C
M-phase inducer phosphatase 3 in PDB entry 2ojx, assembly 1, front view.
M-phase inducer phosphatase 3 in PDB entry 2ojx, assembly 1, side view.
M-phase inducer phosphatase 3 in PDB entry 2ojx, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links