X-ray diffraction
2.3Å resolution

Complement component C2a, the catalytic fragment of C3- and C5-convertase of human complement


Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
C2 Chain: A
Molecule details ›
Chain: A
Length: 509 amino acids
Theoretical weight: 57.46 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: Q5JP69 (Residues: 244-752; Coverage: 70%)
Gene names: C2, hCG_43694
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 51.354Å b: 84.201Å c: 74.426Å
α: 90° β: 92.1° γ: 90°
R R work R free
0.217 0.214 0.274
Expression system: Trichoplusia ni