› 2odc

Solution NMR

LEM-domain of the nuclear envelope protein emerin

Released:
DOI: 10.2210/pdb2odc/pdb
PDB entry 2odc coloured by chain, front view.
PDB entry 2odc coloured by chain, side view.
PDB entry 2odc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution NMR structure of the barrier-to-autointegration factor-Emerin complex.
Cai M, Huang Y, Suh JY, Louis JM, Ghirlando R, Craigie R, Clore GM
J Biol Chem 282 14525-35 (2007)
PMID: 17355960

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Emerin Chain: I
Molecule details ›
Chain: I
Length: 47 amino acids
Theoretical weight: 5.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50402 (Residues: 2-47; Coverage: 18%)
Gene names: EDMD, EMD, STA
Sequence domains: LEM domain
Structure domains: Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: RESTRAINED SIMULATED ANNEALING IN TORION ANGLE SPACE
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation.
Gruenbaum et al. (2015)
12 more

5 mentions without citation

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.
Samson et al. (2018)
4 more