X-ray diffraction
1.5Å resolution

The crystal structure of the first PDZ domain of human NHERF-2 (SLC9A3R2)

Source organism: Homo sapiens
Entry authors: Papagrigoriou E, Phillips C, Gileadi C, Elkins J, Salah E, Berridge G, Savitsky P, Gorrec F, Umeano C, Ugochukwu E, Gileadi O, Burgess N, Edwards A, Arrowsmith CH, Weigelt J, Sundstrom M, Doyle DA, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q15599 (Residues: 9-91; Coverage: 25%)
Gene names: NHERF2, SLC9A3R2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 26.556Å b: 39.867Å c: 37.278Å
α: 90° β: 106.93° γ: 90°
R R work R free
0.154 0.152 0.198
Expression system: Escherichia coli BL21(DE3)