2ocl

X-ray diffraction
1.9Å resolution

Crystal structure of valacyclovir hydrolase S122A mutant

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Valacyclovir hydrolase Chain: A
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 28.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86WA6 (Residues: 38-291; Coverage: 100%)
Gene names: BPHL, MCNAA
Sequence domains: alpha/beta hydrolase fold
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P62
Unit cell:
a: 88.79Å b: 88.79Å c: 86.01Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.184 0.208
Expression system: Escherichia coli BL21(DE3)