X-ray diffraction
1.9Å resolution

Crystal structure of valacyclovir hydrolase complexed with a product analogue

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Valacyclovir hydrolase Chain: A
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 28.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q86WA6 (Residues: 38-291; Coverage: 100%)
Gene names: BPHL, MCNAA
Sequence domains: alpha/beta hydrolase fold
Structure domains: alpha/beta hydrolase

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P62
Unit cell:
a: 88.6Å b: 88.6Å c: 86.71Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.196 0.217
Expression system: Escherichia coli BL21(DE3)