› 2oc3

X-ray diffraction
1.5Å resolution

Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 18

Released:
DOI: 10.2210/pdb2oc3/pdb
PDB entry 2oc3 coloured by chain, front view.
PDB entry 2oc3 coloured by chain, side view.
PDB entry 2oc3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 18 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99952 (Residues: 6-299; Coverage: 64%)
Gene names: BDP1, PTPN18
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 46.338Å b: 63.763Å c: 48.992Å
α: 90° β: 102.64° γ: 90°
R-values:
R R work R free
0.156 0.154 0.184
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

7 mentions without citation

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Yu et al. (2007)
6 more