› 2o42

X-ray diffraction
2.91Å resolution

Crystal Structure of M11L, Bcl-2 homolog from myxoma virus

Released:
DOI: 10.2210/pdb2o42/pdb
PDB 2o42 coloured by chain and viewed from the front.
PDB 2o42 coloured by chain and viewed from the side.
PDB 2o42 coloured by chain and viewed from the top.
Source organism: Myxoma virus
Primary publication:
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2.
Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM
Protein Sci. 16 695-703 (2007)
PMID: 17384234

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator M11L Chains: A, B
Molecule details ›
Chains: A, B
Length: 144 amino acids
Theoretical weight: 16.56 KDa
Source organism: Myxoma virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q85295 (Residues: 1-142; Coverage: 86%)
Gene names: M11L, m011L
Sequence domains: Apoptosis regulator M11L like
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3121
Unit cell:
a: 73.151Å b: 73.151Å c: 186.875Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.249 0.29
Expression system: Escherichia coli

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Citations

20 review citations

Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases.
Ganji et al. (2020)
19 more

6 mentions without citation

Poxvirus proteomics and virus-host protein interactions.
Van Vliet et al. (2009)
5 more