› 2o2e

X-ray diffraction
2.2Å resolution

Mycobacterium tuberculosis tryptophan synthase beta subunit dimer (apoform)

Released:
DOI: 10.2210/pdb2o2e/pdb
PDB entry 2o2e coloured by chain, front view.
PDB entry 2o2e coloured by chain, side view.
PDB entry 2o2e coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Entry authors: Burenkov GP, Kachalova GS, Bartunik HD, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)

Function and Biology Details

Reaction catalysed: 
(1a) 1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161441 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan synthase beta chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 422 amino acids
Theoretical weight: 44.69 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WFX9 (Residues: 1-421; Coverage: 100%)
Gene names: MTCY01B2.04, Rv1612, trpB
Sequence domains: Pyridoxal-phosphate dependent enzyme
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: C2
Unit cell:
a: 125.984Å b: 56.461Å c: 120.545Å
α: 90° β: 117° γ: 90°
R-values:
R R work R free
0.214 0.211 0.281
Expression system: Escherichia coli

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