X-ray diffraction
1.58Å resolution

Crystal structure of phosphoglucose isomerase from T. brucei containing glucose-6-phosphate in the active site


Function and Biology Details

Reaction catalysed:
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glucose-6-phosphate isomerase, glycosomal Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 613 amino acids
Theoretical weight: 68.46 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli
  • Canonical: P13377 (Residues: 1-607; Coverage: 100%)
Gene name: PGI
Sequence domains: Phosphoglucose isomerase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2221
Unit cell:
a: 125.837Å b: 221.253Å c: 128.087Å
α: 90° β: 90° γ: 90°
R R work R free
0.2 0.2 0.213
Expression system: Escherichia coli