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Human spermidine synthase

X-ray diffraction
1.99Å resolution
PDB entry 2o0l coloured by chain, front view.
PDB entry 2o0l coloured by chain, side view.
PDB entry 2o0l coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spermidine synthase
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Multimeric state: homo dimer
Accessible surface area: 21249.31 Å2
Buried surface area: 4900.98 Å2
Dissociation area: 1,700.08 Å2
Dissociation energy (ΔGdiss): 9.77 kcal/mol
Dissociation entropy (TΔSdiss): 13.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148670

Macromolecules

Spermidine synthase
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19623 (Residues: 1-302; Coverage: 100%)
Gene names: SPS1, SRM, SRML1
Pfam:
InterPro:
CATH:
SCOP: Spermidine synthase
Spermidine synthase in PDB entry 2o0l, assembly 1, front view.
Spermidine synthase in PDB entry 2o0l, assembly 1, side view.
Spermidine synthase in PDB entry 2o0l, assembly 1, top view.
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