Function and Biology Details
Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- HEAT, type 2
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- Protein phosphatase 2A, regulatory B subunit, B56
- Metallo-dependent phosphatase-like
- Armadillo-type fold
- Armadillo-like helical
- Calcineurin-like phosphoesterase domain, ApaH type
- Serine/Threonine protein phosphatase PP2A-like
1 more domain
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-151659 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Molecule details ›
Chains: A, D
Length: 582 amino acids
Theoretical weight: 65.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Length: 582 amino acids
Theoretical weight: 65.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P30153 (Residues: 8-589; Coverage: 99%)
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Molecule details ›
Chains: B, E
Length: 388 amino acids
Theoretical weight: 46.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Protein phosphatase 2A regulatory B subunit (B56 family)
Structure domains: Leucine-rich Repeat Variant
Length: 388 amino acids
Theoretical weight: 46.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q13362 (Residues: 38-425; Coverage: 74%)
Sequence domains: Protein phosphatase 2A regulatory B subunit (B56 family)
Structure domains: Leucine-rich Repeat Variant
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Molecule details ›
Chains: C, F
Length: 293 amino acids
Theoretical weight: 33.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Length: 293 amino acids
Theoretical weight: 33.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P67775 (Residues: 2-294; Coverage: 95%)
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
