› 2nuo

X-ray diffraction
1.5Å resolution

Crystal structure of a complex of griffithsin with glucose

Released:
DOI: 10.2210/pdb2nuo/pdb
PDB 2nuo coloured by chain and viewed from the front.
PDB 2nuo coloured by chain and viewed from the side.
PDB 2nuo coloured by chain and viewed from the top.
Source organism: Griffithsia
Primary publication:
Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine.
Ziółkowska NE, Shenoy SR, O'Keefe BR, Wlodawer A
Protein Sci. 16 1485-9 (2007)
PMID: 17567736

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Griffithsin Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 12.73 KDa
Source organism: Griffithsia
Expression system: Nicotiana benthamiana
UniProt:
  • Canonical: P84801 (Residues: 1-121; Coverage: 100%)
Sequence domains: Jacalin-like lectin domain
Structure domains: Jacalin-like lectin domain

Ligands and Environments

3 bound ligands:
Ligand BGC 6 x BGC
Ligand SO4 1 x SO4
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 37.49Å b: 53.67Å c: 103.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.203
Expression system: Nicotiana benthamiana

Quick links

Citations

5 review citations

Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application.
Lee C. (2019)
4 more

2 mentions without citation

Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.
Barre et al. (2019)
1 more