› 2ntd

X-ray diffraction
2.52Å resolution

Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations

Released:
DOI: 10.2210/pdb2ntd/pdb
PDB entry 2ntd coloured by chain, front view.
PDB entry 2ntd coloured by chain, side view.
PDB entry 2ntd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions.
Dubey VK, Lee J, Somasundaram T, Blaber S, Blaber M
J Mol Biol 371 256-68 (2007)
PMID: 17570396

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 146 amino acids
Theoretical weight: 16.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand FMT 11 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 60.6Å b: 108.33Å c: 60.92Å
α: 90° β: 104.97° γ: 90°
R-values:
R R work R free
0.173 0.173 0.229
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The FGF family: biology, pathophysiology and therapy.
Beenken et al. (2009)
4 more

1 mention without citation

Francisella RNA polymerase contains a heterodimer of non-identical α subunits.
Mukhamedyarov et al. (2011)