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C28A Mutant of Succinyl-CoA:3-Ketoacid CoA Transferase from Pig Heart

Source organism: Sus scrofa
Biochemical function: protein homodimerization activity
Biological process: ketone body catabolic process
Cellular component: mitochondrion

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EC 2.8.3.5: 3-oxoacid CoA-transferase

Reaction catalysed:
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA
Systematic name:
Succinyl-CoA:3-oxo-acid CoA-transferase
Alternative Name(s):
  • 3-ketoacid CoA-transferase
  • 3-ketoacid coenzyme A transferase
  • 3-oxo-CoA transferase
  • 3-oxoacid CoA dehydrogenase
  • 3-oxoacid coenzyme A-transferase
  • Acetoacetate succinyl-CoA transferase
  • Acetoacetyl coenzyme A-succinic thiophorase
  • Succinyl coenzyme A-acetoacetyl coenzyme A-transferase
  • Succinyl-CoA transferase
  • Succinyl-CoA:3-ketoacid-CoA transferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01144
Domain description: Coenzyme A transferase
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
The deposited structure of PDB entry 2nrc contains 8 copies of Pfam domain PF01144 (Coenzyme A transferase) in Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial. Showing 2 copies in chain B.

InterPro InterPro annotations
IPR004165
Domain description: Coenzyme A transferase family I
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
IPR037171
Domain description: NagB/RpiA transferase-like
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
IPR004164
Domain description: Coenzyme A transferase active site
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
IPR012791
Domain description: 3-oxoacid CoA-transferase, subunit B
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
IPR004163
Domain description: Coenzyme A transferase binding site
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
IPR012792
Domain description: 3-oxoacid CoA-transferase, subunit A
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
IPR014388
Domain description: 3-oxoacid CoA-transferase
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Structure domain

CATH CATH domain
3.40.1080.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaconate Coenzyme A-transferase
Homology: Glutaconate Coenzyme A-transferase
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
The deposited structure of PDB entry 2nrc contains 8 copies of CATH domain 3.40.1080.10 (Glutaconate Coenzyme A-transferase) in Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial. Showing 2 copies in chain B.
SCOP SCOP annotations
74657
Class: Alpha and beta proteins (a/b)
Fold: NagB/RpiA/CoA transferase-like
Superfamily: NagB/RpiA/CoA transferase-like
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
The deposited structure of PDB entry 2nrc contains 4 copies of SCOP domain 74657 (CoA transferase beta subunit-like) in Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial. Showing 1 copy in chain B.
74656
Class: Alpha and beta proteins (a/b)
Fold: NagB/RpiA/CoA transferase-like
Superfamily: NagB/RpiA/CoA transferase-like
Occurring in:
  1. Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
The deposited structure of PDB entry 2nrc contains 4 copies of SCOP domain 74656 (CoA transferase alpha subunit-like) in Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial. Showing 1 copy in chain B.

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