› 2noy

X-ray diffraction
1.8Å resolution

Crystal structure of transthyretin mutant I84S at PH 7.5

Released:
DOI: 10.2210/pdb2noy/pdb
PDB entry 2noy coloured by chain, front view.
PDB entry 2noy coloured by chain, side view.
PDB entry 2noy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Acidic pH-induced conformational changes in amyloidogenic mutant transthyretin.
Pasquato N, Berni R, Folli C, Alfieri B, Cendron L, Zanotti G
J Mol Biol 366 711-9 (2007)
PMID: 17196219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21212
Unit cell:
a: 42.902Å b: 85.344Å c: 65.375Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.195 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Impact of oligomerization on the allergenicity of allergens.
Hasan-Abad et al. (2022)
21 other articles

1 mention without citation

Predicting binding sites from unbound versus bound protein structures.
Clark et al. (2020)