2nmp

X-ray diffraction
2.6Å resolution

Crystal structure of human Cystathionine gamma lyase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystathionine gamma-lyase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 403 amino acids
Theoretical weight: 44.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P32929 (Residues: 1-402; Coverage: 99%)
Gene name: CTH
Sequence domains: Cys/Met metabolism PLP-dependent enzyme
Structure domains:

Ligands and Environments


Cofactor: Ligand PLP 3 x PLP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 105.78Å b: 107.57Å c: 153.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.245
Expression system: Escherichia coli BL21(DE3)