X-ray diffraction
1.68Å resolution

Crystal structure of dihydroneopterin aldolase from S. aureus in complex with (1S,2S)-monapterin at 1.68 angstrom resolution


Function and Biology Details

Reactions catalysed:
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
7,8-dihydroneopterin = 7,8-dihydromonapterin
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Dihydroneopterin aldolase Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.77 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
  • Canonical: P56740 (Residues: 1-121; Coverage: 100%)
Gene name: folB
Sequence domains: Dihydroneopterin aldolase
Structure domains: GTP Cyclohydrolase I, domain 2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: I422
Unit cell:
a: 61.191Å b: 61.191Å c: 124.528Å
α: 90° β: 90° γ: 90°
R R work R free
0.227 not available 0.262
Expression system: Escherichia coli