X-ray diffraction
2.8Å resolution

Crystal structure of the Mcl-1:mNoxaB BH3 complex

Source organisms:
Primary publication:
Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc. Natl. Acad. Sci. U.S.A. 104 6217-22 (2007)
PMID: 17389404

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.82 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q07820 (Residues: 241-327; Coverage: 25%)
  • Canonical: P97287 (Residues: 152-221; Coverage: 21%)
Gene names: BCL2L3, MCL1, Mcl1
Structure domains: Blc2-like
Phorbol-12-myristate-13-acetate-induced protein 1 Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 3.01 KDa
Source organism: Mus musculus
  • Canonical: Q9JM54 (Residues: 68-93; Coverage: 25%)
Gene names: Noxa, Pmaip1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P63
Unit cell:
a: 85.381Å b: 85.381Å c: 46.916Å
α: 90° β: 90° γ: 120°
R R work R free
0.211 0.207 0.291
Expression system: Escherichia coli BL21(DE3)