› 2na2

Solution NMR

DROSHA QUAD MUTANT DOUBLE-STRANDED RNA BINDING COMPETENT

Released:
DOI: 10.2210/pdb2na2/pdb
PDB entry 2na2 coloured by chain, ensemble of 10 models, front view.
PDB entry 2na2 coloured by chain, ensemble of 10 models, side view.
PDB entry 2na2 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Entry authors: Showalter SA, Sahu D, Kranick JC

Function and Biology Details

Reaction catalysed: 
Endonucleolytic cleavage to 5'-phosphomonoester.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease 3 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 8.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NRR4 (Residues: 1259-1337; Coverage: 6%)
Gene names: DROSHA, RN3, RNASE3L, RNASEN
Sequence domains: Double-stranded RNA binding motif
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 69%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

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