› 2n7x

Solution NMR

Solution structure of microRNA 20b pre-element

Released:
DOI: 10.2210/pdb2n7x/pdb
PDB entry 2n7x coloured by chain, ensemble of 20 models, front view.
PDB entry 2n7x coloured by chain, ensemble of 20 models, side view.
PDB entry 2n7x coloured by chain, ensemble of 20 models, top view.
Source organism: synthetic construct
Primary publication:
Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.
Chen Y, Zubovic L, Yang F, Godin K, Pavelitz T, Castellanos J, Macchi P, Varani G
Nucleic Acids Res 44 4381-95 (2016)
PMID: 27001519

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196527 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*CP*UP*CP*UP*AP*CP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 23 nucleotides
Theoretical weight: 7.32 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 73%
Refinement method: restrained simulated annealing
Expression system: Not provided

Quick links

Citations

14 review citations

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways.
Treiber et al. (2019)
13 more

4 mentions without citation

Principles for targeting RNA with drug-like small molecules.
Warner et al. (2018)
3 more