2n1i

Solution NMR

Structure of the PR domain from PRDM16

Released:
Source organism: Homo sapiens
Entry authors: Sun Y, Armstrong G, Briknarova K

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase PRDM16 Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 19.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HAZ2 (Residues: 54-226; Coverage: 14%)
Gene names: KIAA1675, MEL1, PFM13, PRDM16

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: molecular dynamics
Chemical shifts: BMR25562  
Expression system: Escherichia coli BL21(DE3)