Solution NMR

The solution structure of the MANEC-type domain from Hepatocyte Growth Factor Inhibitor 1 reveals an unexpected PAN/apple domain-type fold


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Kunitz-type protease inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: O43278 (Residues: 47-152; Coverage: 22%)
Gene names: HAI1, SPINT1, UNQ223/PRO256

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: DGSA-distance geometry simulated annealing
Chemical shifts: BMR25139  
Expression system: Komagataella pastoris