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Structure of complex of MDM2(3-109) and P73 TAD(10-25)

Solution NMR
PDB 2mps coloured by chain and viewed from the front.
PDB 2mps coloured by chain and viewed from the side.
PDB 2mps coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
Non-polymer only dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: Non-polymer only dimer

Binding statistics and energies are not available for this assembly

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chain: A
Length: 107 amino acids
Theoretical weight: 12.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00987 (Residues: 3-109; Coverage: 22%)
Gene name: MDM2
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
PDB 2mps contains 1 copy of E3 ubiquitin-protein ligase Mdm2 in assembly 1. This protein is highlighted and viewed from the front.
PDB 2mps contains 1 copy of E3 ubiquitin-protein ligase Mdm2 in assembly 1. This protein is highlighted and viewed from the side.
PDB 2mps contains 1 copy of E3 ubiquitin-protein ligase Mdm2 in assembly 1. This protein is highlighted and viewed from the top.
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Tumor protein p73
Chain: B
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15350 (Residues: 10-25; Coverage: 3%)
Gene names: P73, TP73
PDB 2mps contains 1 copy of Tumor protein p73 in assembly 1. This protein is highlighted and viewed from the front.
PDB 2mps contains 1 copy of Tumor protein p73 in assembly 1. This protein is highlighted and viewed from the side.
PDB 2mps contains 1 copy of Tumor protein p73 in assembly 1. This protein is highlighted and viewed from the top.
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