PDBe 2mfq

Solution NMR

NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor receptor substrate 2 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8WU20 (Residues: 11-122; Coverage: 22%)
Gene name: FRS2
Sequence domains: PTB domain (IRS-1 type)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
BDNF/NT-3 growth factors receptor Chain: B
Molecule details ›
Chain: B
Length: 23 amino acids
Theoretical weight: 2.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q16620 (Residues: 497-519; Coverage: 3%)
Gene names: NTRK2, TRKB

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Chemical shifts: BMR19562  
Expression systems:
  • Escherichia coli
  • Not provided