› 2me3

Solution NMR

HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle

Released:
DOI: 10.2210/pdb2me3/pdb
PDB entry 2me3 coloured by chain, ensemble of 10 models, front view.
PDB entry 2me3 coloured by chain, ensemble of 10 models, side view.
PDB entry 2me3 coloured by chain, ensemble of 10 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Disruption of helix-capping residues 671 and 674 reveals a role in HIV-1 entry for a specialized hinge segment of the membrane proximal external region of gp41.
Sun ZY, Cheng Y, Kim M, Song L, Choi J, Kudahl UJ, Brusic V, Chowdhury B, Yu L, Seaman MS, Bellot G, Shih WM, Wagner G, Reinherz EL
J Mol Biol 426 1095-108 (2014)
PMID: 24075869

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 3.51 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q202K4 (Residues: 636-662; Coverage: 3%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Evolution of Structural DNA Nanotechnology.
Nummelin et al. (2018)
1 more

2 mentions without citation

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.
Padmanabha Das et al. (2018)
1 more