› 2mcc

Solution NMR

Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an anti-parallel folded human telomere sequence

Released:
DOI: 10.2210/pdb2mcc/pdb
PDB entry 2mcc coloured by chain, ensemble of 5 models, front view.
PDB entry 2mcc coloured by chain, ensemble of 5 models, side view.
PDB entry 2mcc coloured by chain, ensemble of 5 models, top view.
Source organism: Synthetic construct
Primary publication:
Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence.
Wilson T, Costa PJ, Félix V, Williamson MP, Thomas JA
J Med Chem 56 8674-83 (2013)
PMID: 24088028

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115607 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
human_telomere_quadruplex Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 6.98 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand RUL 1 x RUL
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 40%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

3 review citations

Insights from Binding on Quadruplex Selective Carbazole Ligands.
Müller et al. (2021)
2 more

3 mentions without citation

Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures.
Criscuolo et al. (2022)
2 more