› 2m8k

Solution NMR

A pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo

Released:
DOI: 10.2210/pdb2m8k/pdb
PDB entry 2m8k coloured by chain, ensemble of 20 models, front view.
PDB entry 2m8k coloured by chain, ensemble of 20 models, side view.
PDB entry 2m8k coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo.
Cash DD, Cohen-Zontag O, Kim NK, Shefer K, Brown Y, Ulyanov NB, Tzfati Y, Feigon J
Proc Natl Acad Sci U S A 110 10970-5 (2013)
PMID: 23776224

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196495 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (48-MER) Chain: A
Molecule details ›
Chain: A
Length: 48 nucleotides
Theoretical weight: 15.15 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 65%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

9 review citations

Evolutionary perspectives of telomerase RNA structure and function.
Podlevsky et al. (2016)
8 more

10 mentions without citation

Progress in Human and Tetrahymena Telomerase Structure Determination.
Chan et al. (2017)
9 more