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Solution NMR

Refined solution structure of Human Adult Hemoglobin in the Carbonmonoxy Form

Released:
DOI: 10.2210/pdb2m6z/pdb
PDB 2m6z coloured by chain and viewed from the front.
PDB 2m6z coloured by chain and viewed from the side.
PDB 2m6z coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Solution structure and dynamics of human hemoglobin in the carbonmonoxy form.
Fan JS, Zheng Y, Choy WY, Simplaceanu V, Ho NT, Ho C, Yang D
Biochemistry 52 5809-20 (2013)
PMID: 23901897

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

1 bound ligand:
Ligand HEC 4 x HEC
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 37%
Refinement method: torsion angle dynamics
Chemical shifts: BMR7125  
Expression system: Escherichia coli

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Citations

1 review citation

Hemoglobin: Structure, Function and Allostery.
Ahmed et al. (2020)
4 other articles

5 mentions without citation

New look at hemoglobin allostery.
Yuan et al. (2015)
4 more