PDBe 2m0v

Solution NMR

Complex structure of C-terminal CFTR peptide and extended PDZ2 domain from NHERF1


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O14745 (Residues: 150-270; Coverage: 34%)
Gene names: NHERF, NHERF1, SLC9A3R1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
C-terminal CFTR peptide Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 633 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Chemical shifts: BMR18826  
Expression systems:
  • Escherichia coli
  • Not provided