› 2ly0

Solution NMR

Solution NMR structure of the influenza A virus S31N mutant (19-49) in presence of drug M2WJ332

Released:
DOI: 10.2210/pdb2ly0/pdb
PDB entry 2ly0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ly0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ly0 coloured by chain, ensemble of 20 models, top view.
Source organism: Influenza A virus (A/Chiba/5/71(H3N2))
Primary publication:
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.
Wang J, Wu Y, Ma C, Fiorin G, Wang J, Pinto LH, Lamb RA, Klein ML, Degrado WF
Proc Natl Acad Sci U S A 110 1315-20 (2013)
PMID: 23302696

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 31 amino acids
Theoretical weight: 3.5 KDa
Source organism: Influenza A virus (A/Chiba/5/71(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: Q6XT21 (Residues: 20-49; Coverage: 31%)
Gene name: M
Sequence domains: Influenza Matrix protein (M2)

Ligands and Environments

1 bound ligand:
Ligand A2Y 1 x A2Y
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 21%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

21 review citations

Fusion of Enveloped Viruses in Endosomes.
White et al. (2016)
20 more

28 mentions without citation

Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Jalily et al. (2020)
27 more