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Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains.

Liu S, Chen Y, Li J, Huang T, Tarasov S, King A, Weissman AM, Byrd RA, Das R
Structure 20 2138-50 (2012)
Related entries: 2lvn, 2lvp, 2lvq

Cited: 25 times
EuropePMC logo PMID: 23123110

Abstract

Recognition of ubiquitin and polyubiquitin chains by ubiquitin-binding domains (UBDs) is vital for ubiquitin-mediated signaling pathways. The endoplasmic reticulum resident RING finger ubiquitin ligase (E3) gp78 regulates critical proteins via the ubiquitin-proteasome system to maintain cellular homeostasis and includes a UBD known as the CUE domain, which is essential for function. A probable role of this domain is to recognize ubiquitin-modified substrates, enabling gp78 to assemble polyubiquitin chains on these substrates and mark them for degradation. Here, we report the molecular details of the interaction of gp78CUE domain with ubiquitin and diubiquitin. The gp78CUE domain exhibits a well-defined set of interactions with ubiquitin and a dynamic, promiscuous interaction with diubiquitin chains. This leads to a model in which the CUE domain functions to both facilitate substrate binding and enable switching between adjacent ubiquitin molecules of a growing chain to enable processivity in ubiquitination.

Articles - 2lvo mentioned but not cited (3)

  1. Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains. Liu S, Chen Y, Li J, Huang T, Tarasov S, King A, Weissman AM, Byrd RA, Das R. Structure 20 2138-2150 (2012)
  2. Enhancing NMR derived ensembles with kinetics on multiple timescales. Smith CA, Mazur A, Rout AK, Becker S, Lee D, de Groot BL, Griesinger C. J Biomol NMR 74 27-43 (2020)
  3. The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin. Lombardi PM, Haile S, Rusanov T, Rodell R, Anoh R, Baer JG, Burke KA, Gray LN, Hacker AR, Kebreau KR, Ngandu CK, Orland HA, Osei-Asante E, Schmelyun DP, Shorb DE, Syed SH, Veilleux JM, Majumdar A, Mosammaparast N, Wolberger C. J Biol Chem 298 101545 (2022)


Reviews citing this publication (2)

  1. Cleaning up in the endoplasmic reticulum: ubiquitin in charge. Christianson JC, Ye Y. Nat Struct Mol Biol 21 325-335 (2014)
  2. Ubiquitination in the ERAD Process. Lopata A, Kniss A, Löhr F, Rogov VV, Dötsch V. Int J Mol Sci 21 E5369 (2020)

Articles citing this publication (20)

  1. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N. Nature 551 389-393 (2017)
  2. Efficient and generalized processing of multidimensional NUS NMR data: the NESTA algorithm and comparison of regularization terms. Sun S, Gill M, Li Y, Huang M, Byrd RA. J Biomol NMR 62 105-117 (2015)
  3. A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. Kristariyanto YA, Abdul Rehman SA, Weidlich S, Knebel A, Kulathu Y. EMBO Rep 18 392-402 (2017)
  4. Disruption of gene SPL35, encoding a novel CUE domain-containing protein, leads to cell death and enhanced disease response in rice. Ma J, Wang Y, Ma X, Meng L, Jing R, Wang F, Wang S, Cheng Z, Zhang X, Jiang L, Wang J, Wang J, Zhao Z, Guo X, Lin Q, Wu F, Zhu S, Wu C, Ren Y, Lei C, Zhai H, Wan J. Plant Biotechnol J 17 1679-1693 (2019)
  5. The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation. von Delbrück M, Kniss A, Rogov VV, Pluska L, Bagola K, Löhr F, Güntert P, Sommer T, Dötsch V. Mol Cell 62 918-928 (2016)
  6. Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. Liu Z, Dong X, Yi HW, Yang J, Gong Z, Wang Y, Liu K, Zhang WP, Tang C. Cell Discov 5 19 (2019)
  7. A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi. Berk JM, Lim C, Ronau JA, Chaudhuri A, Chen H, Beckmann JF, Loria JP, Xiong Y, Hochstrasser M. Nat Commun 11 2343 (2020)
  8. Optimization of sortase A ligation for flexible engineering of complex protein systems. Li J, Zhang Y, Soubias O, Khago D, Chao FA, Li Y, Shaw K, Byrd RA. J Biol Chem 295 2664-2675 (2020)
  9. A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin. Lim M, Newman JA, Williams HL, Masino L, Aitkenhead H, Gravard AE, Gileadi O, Svejstrup JQ. Structure 27 1316-1325.e6 (2019)
  10. An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure. Lu X, Ebelle DL, Matsuo H, Walters KJ. Structure 28 495-506.e3 (2020)
  11. gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains. Liu W, Shang Y, Li W. Sci Rep 4 7138 (2014)
  12. Comparison of native and non-native ubiquitin oligomers reveals analogous structures and reactivities. Pham GH, Rana AS, Korkmaz EN, Trang VH, Cui Q, Strieter ER. Protein Sci 25 456-471 (2016)
  13. The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. Budhidarmo R, Day CL. J Biol Chem 289 25721-25736 (2014)
  14. Structural characterization of the late competence protein ComFB from Bacillus subtilis. Sysoeva TA, Bane LB, Xiao DY, Bose B, Chilton SS, Gaudet R, Burton BM. Biosci Rep 35 e00183 (2015)
  15. Ubc7/Ube2g2 ortholog in Entamoeba histolytica: connection with the plasma membrane and phagocytosis. Kumari R, Gupta P, Tiwari S. Parasitol Res 117 1599-1611 (2018)
  16. NMR Characterization of Conformational Interconversions of Lys48-Linked Ubiquitin Chains. Hiranyakorn M, Yanaka S, Satoh T, Wilasri T, Jityuti B, Yagi-Utsumi M, Kato K. Int J Mol Sci 21 E5351 (2020)
  17. A simple protocol for the production of highly deuterated proteins for biophysical studies. Li J, Byrd RA. J Biol Chem 298 102253 (2022)
  18. A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation. Smith CE, Tsai YC, Liang YH, Khago D, Mariano J, Li J, Tarasov SG, Gergel E, Tsai B, Villaneuva M, Clapp ME, Magidson V, Chari R, Byrd RA, Ji X, Weissman AM. PLoS Biol 19 e3001474 (2021)
  19. Exploring Sulfur Sites in Proteins via Triple-Resonance 1H-Detected 77Se NMR. Koscielniak J, Li J, Sail D, Swenson R, Anklin C, Rozovsky S, Byrd RA. J Am Chem Soc (2023)
  20. The Ubiquitin Interacting Motif-Like Domain of Met4 Selectively Binds K48 Polyubiquitin Chains. Villamil M, Xiao W, Yu C, Huang L, Xu P, Kaiser P. Mol Cell Proteomics 21 100175 (2022)


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