› 2ltk

Solution NMR

Solution structure of a monomeric truncated mutant of Trypanosoma brucei 1-C-Grx1

Released:
DOI: 10.2210/pdb2ltk/pdb
PDB entry 2ltk coloured by chain, ensemble of 20 models, front view.
PDB entry 2ltk coloured by chain, ensemble of 20 models, side view.
PDB entry 2ltk coloured by chain, ensemble of 20 models, top view.
Source organism: Trypanosoma brucei
Primary publication:
Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity.
Manta B, Pavan C, Sturlese M, Medeiros A, Crispo M, Berndt C, Krauth-Siegel RL, Bellanda M, Comini MA
Antioxid Redox Signal 19 665-82 (2013)
PMID: 23259530

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.33 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2UZM9 (Residues: 76-184; Coverage: 59%)
Gene name: mgrx
Sequence domains: Glutaredoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Glutathione, Glutaredoxins, and Iron.
Berndt et al. (2017)
2 more

3 mentions without citation

Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes.
Comini et al. (2013)
2 more