PDBe 2loz

Solution NMR

The novel binding mode of DLC1 and Tensin2 PTB domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tensin-2 Chain: A
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63HR2 (Residues: 1263-1409; Coverage: 10%)
Gene names: KIAA1075, TENC1, TNS2
Sequence domains: Phosphotyrosine-binding domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Rho GTPase-activating protein 7 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96QB1 (Residues: 811-824; Coverage: 1%)
Gene names: ARHGAP7, DLC1, KIAA1723, STARD12

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 75%
Refinement method: torsion angle dynamics, molecular dynamics
Chemical shifts: BMR17364  
Expression system: Escherichia coli