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Enterohaemorrhagic E. coli (EHEC) exploits a tryptophan switch to hijack host F-actin assembly

Solution NMR
PDB entry 2lnh coloured by chain, ensemble of 20 models, front view.
PDB entry 2lnh coloured by chain, ensemble of 20 models, side view.
PDB entry 2lnh coloured by chain, ensemble of 20 models, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 12503.98 Å2
Buried surface area: 3060.17 Å2
Dissociation area: 758.11 Å2
Dissociation energy (ΔGdiss): 2.92 kcal/mol
Dissociation entropy (TΔSdiss): 10.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126257

Macromolecules

Actin nucleation-promoting factor WASL
Chain: A
Length: 65 amino acids
Theoretical weight: 7.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00401 (Residues: 207-270; Coverage: 13%)
Gene name: WASL
Pfam: P21-Rho-binding domain
InterPro:
CATH: CRIB domain
Actin nucleation-promoting factor WASL in PDB entry 2lnh, assembly 1, front view.
Actin nucleation-promoting factor WASL in PDB entry 2lnh, assembly 1, side view.
Actin nucleation-promoting factor WASL in PDB entry 2lnh, assembly 1, top view.
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BAR/IMD domain-containing adapter protein 2-like 1
Chain: B
Length: 67 amino acids
Theoretical weight: 7.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHR4 (Residues: 339-402; Coverage: 13%)
Gene names: BAIAP2L1, IRTKS
Pfam: Variant SH3 domain
InterPro:
CATH: SH3 Domains
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 in PDB entry 2lnh, assembly 1, front view.
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 in PDB entry 2lnh, assembly 1, side view.
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 in PDB entry 2lnh, assembly 1, top view.
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Secreted effector protein EspF(U)
Chain: C
Length: 48 amino acids
Theoretical weight: 5.3 KDa
Source organism: Escherichia coli O157:H7
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DJ89 (Residues: 268-314; Coverage: 14%)
Gene names: espF(U), tccP
Pfam: EspF protein repeat
InterPro:
CATH: TccP2/EspF(U)-like
Secreted effector protein EspF(U) in PDB entry 2lnh, assembly 1, front view.
Secreted effector protein EspF(U) in PDB entry 2lnh, assembly 1, side view.
Secreted effector protein EspF(U) in PDB entry 2lnh, assembly 1, top view.
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