› 2lm5

Solution NMR

Solution structure of Ca2+-CIB1 in complex with the cytoplasmic domain of the integrin aIIb subunit

Released:
DOI: 10.2210/pdb2lm5/pdb
PDB entry 2lm5 coloured by chain, ensemble of 10 models, front view.
PDB entry 2lm5 coloured by chain, ensemble of 10 models, side view.
PDB entry 2lm5 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the activation of platelet integrin αIIbβ3 by calcium- and integrin-binding protein 1.
Huang H, Vogel HJ
J Am Chem Soc 134 3864-72 (2012)
PMID: 22283712

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189279 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium and integrin-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 24.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99828 (Residues: 1-191; Coverage: 100%)
Gene names: CIB, CIB1, KIP, PRKDCIP
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

CIB1: a small protein with big ambitions.
Leisner et al. (2016)
2 more

5 mentions without citation

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.
Riazuddin et al. (2012)
4 more