› 2llp

Solution NMR

Solution structure of a THP type 1 alpha 1 collagen fragment (772-786)

Released:
DOI: 10.2210/pdb2llp/pdb
PDB entry 2llp coloured by chain, ensemble of 30 models, front view.
PDB entry 2llp coloured by chain, ensemble of 30 models, side view.
PDB entry 2llp coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis.
Bertini I, Fragai M, Luchinat C, Melikian M, Toccafondi M, Lauer JL, Fields GB
J Am Chem Soc 134 2100-10 (2012)
PMID: 22239621

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135851 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagen alpha-1(I) chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 18 amino acids
Theoretical weight: 1.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02452 (Residues: 949-965; Coverage: 1%)
Gene name: COL1A1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing, minimisation
Expression system: Not provided

Quick links

Citations

18 review citations

Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets.
Hadler-Olsen et al. (2013)
17 more

3 mentions without citation

Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis.
Bertini et al. (2012)
2 more