› 2ljc

Solution NMR

Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine

Released:
DOI: 10.2210/pdb2ljc/pdb
PDB entry 2ljc coloured by chain, ensemble of 15 models, front view.
PDB entry 2ljc coloured by chain, ensemble of 15 models, side view.
PDB entry 2ljc coloured by chain, ensemble of 15 models, top view.
Source organism: Influenza A virus H3N2
Primary publication:
Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.
Pielak RM, Oxenoid K, Chou JJ
Structure 19 1655-63 (2011)
PMID: 22078564

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 35 amino acids
Theoretical weight: 3.81 KDa
Source organism: Influenza A virus H3N2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9YP62 (Residues: 18-46; Coverage: 30%)
Gene name: M

Ligands and Environments

1 bound ligand:
Ligand RIM 1 x RIM
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 4%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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Citations

13 review citations

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.
Wanka et al. (2013)
12 more

5 mentions without citation

Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.
Zhou et al. (2013)
4 more