› 2le6

Solution NMR

Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface

Released:
DOI: 10.2210/pdb2le6/pdb
PDB entry 2le6 coloured by chain, ensemble of 10 models, front view.
PDB entry 2le6 coloured by chain, ensemble of 10 models, side view.
PDB entry 2le6 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity.
Do NQ, Lim KW, Teo MH, Heddi B, Phan AT
Nucleic Acids Res 39 9448-57 (2011)
PMID: 21840903

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115534 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*IP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 16 nucleotides
Theoretical weight: 5.11 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 18%
Refinement method: DGSA-distance geometry simulated annealing, distance-restrained molecular dynamics refinement in vacuo, distance-restrained molecular dynamics refinement in explicit solvent
Expression system: Not provided

Quick links

Citations

13 review citations

Circular dichroism and guanine quadruplexes.
Vorlíčková et al. (2012)
12 more

13 mentions without citation

G-quadruplexes in viruses: function and potential therapeutic applications.
Métifiot et al. (2014)
12 more