2le4

Solution NMR

Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2

Released:
Source organism: Homo sapiens
Entry authors: Sahu SC, Markley JL, Tonelli M, Bahrami A, Eghbalnia HR, Center for Eukaryotic Structural Genomics (CESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor SOX-2 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48431 (Residues: 39-118; Coverage: 25%)
Gene name: SOX2
Sequence domains: HMG (high mobility group) box
Structure domains: High mobility group box domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: molecular dynamics
Chemical shifts: BMR17691  
Expression system: Escherichia coli