2la6

Solution NMR

Solution NMR Structure of RRM domain of RNA-binding protein FUS from homo sapiens, Northeast Structural Genomics Consortium Target HR6430A

Released:
Source organism: Homo sapiens
Entry authors: Liu G, Xiao R, Janjua H, Ciccosanti C, Wang H, Lee H, Acton TB, Everett JK, Huang YJ, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein FUS Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35637 (Residues: 282-370; Coverage: 17%)
Gene names: FUS, TLS
Sequence domains: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: distance geometry, torsion angle dynamics, simulated annealing, molecular dynamics
Chemical shifts: BMR17508  
Expression system: Escherichia coli