› 2l9n

Solution NMR

Structure of the human Shwachman-Bodian-Diamond syndrome (SBDS) protein

Released:
DOI: 10.2210/pdb2l9n/pdb
PDB entry 2l9n coloured by chain, ensemble of 20 models, front view.
PDB entry 2l9n coloured by chain, ensemble of 20 models, side view.
PDB entry 2l9n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Finch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, González Fernández A, Simpson P, D'Santos CS, Arends MJ, Donadieu J, Bellanné-Chantelot C, Costanzo M, Boone C, McKenzie AN, Freund SM, Warren AJ
Genes Dev 25 917-29 (2011)
PMID: 21536732

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195187 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosome maturation protein SBDS Chain: A
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 28.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3A5 (Residues: 1-250; Coverage: 100%)
Gene names: CGI-97, SBDS
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

53 review citations

Ribosome biogenesis in the yeast Saccharomyces cerevisiae.
Woolford et al. (2013)
52 more

4 mentions without citation

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Finch et al. (2011)
3 more