› 2l7m

Solution NMR

Solution Structure of the Pitx2 Homeodomain R24H mutant

Released:
DOI: 10.2210/pdb2l7m/pdb
PDB entry 2l7m coloured by chain, ensemble of 20 models, front view.
PDB entry 2l7m coloured by chain, ensemble of 20 models, side view.
PDB entry 2l7m coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Doerdelmann T, Rance M, Kojetin DJ, Baird-Titus JM

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189247 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pituitary homeobox 2 Chain: P
Molecule details ›
Chain: P
Length: 68 amino acids
Theoretical weight: 8.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99697 (Residues: 85-144; Coverage: 19%)
Gene names: ARP1, PITX2, RGS, RIEG, RIEG1
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: molecular dynamics
Expression system: Escherichia coli

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