› 2kvd

Solution NMR

Mesencephalic astrocyte-derived neurotrophic factor (MANF)

Released:
DOI: 10.2210/pdb2kvd/pdb
PDB entry 2kvd coloured by chain, ensemble of 15 models, front view.
PDB entry 2kvd coloured by chain, ensemble of 15 models, side view.
PDB entry 2kvd coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.
Hellman M, Arumäe U, Yu LY, Lindholm P, Peränen J, Saarma M, Permi P
J Biol Chem 286 2675-80 (2011)
PMID: 21047780

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mesencephalic astrocyte-derived neurotrophic factor Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55145 (Residues: 25-182; Coverage: 100%)
Gene names: ARMET, ARP, MANF
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: TORSION ANGLE DYNAMICS, simulated annealing, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy.
Domanskyi et al. (2015)
16 more

5 mentions without citation

Trophic activities of endoplasmic reticulum proteins CDNF and MANF.
Jӓntti et al. (2020)
4 more