2ksb

Solution NMR

Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Substance-P receptor Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 41.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25103 (Residues: 1-364; Coverage: 89%)
Gene names: NK1R, TAC1R, TACR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins
Substance P Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20366 (Residues: 58-68; Coverage: 10%)
Gene names: NKA, NKNA, TAC1, TAC2
Sequence domains: Tachykinin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 1%
Refinement method: molecular dynamics, simulated annealing
Chemical shifts: BMR20117  
Expression system: Not provided