PDBe 2ks9

Solution NMR

Solution conformation of substance P in water complexed with NK1R

Released:
Source organism: Homo sapiens
Primary publication:
NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles.
Biochim. Biophys. Acta 1808 127-39 (2011)
PMID: 20937248

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Substance-P receptor Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 41.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25103 (Residues: 1-364; Coverage: 89%)
Gene names: NK1R, TAC1R, TACR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhopdopsin 7-helix transmembrane proteins
Substance P Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20366 (Residues: 58-68; Coverage: 10%)
Gene names: NKA, NKNA, TAC1, TAC2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 2%
Refinement method: molecular dynamics, simulated annealing
Chemical shifts: BMR20115   BMR16660  
Expression system: Not provided