2kq6

Solution NMR

The structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycystin-2 Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 9.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13563 (Residues: 720-797; Coverage: 8%)
Gene names: PKD2, TRPP2
Structure domains: EF-hand

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 68%
Refinement method: XPLOR-NIH
Chemical shifts: BMR16590  
Expression system: Escherichia coli