PDBe 2ki6

Solution NMR

The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Synaptotagmin-1 Chains: A, F
Molecule details ›
Chains: A, F
Length: 128 amino acids
Theoretical weight: 14.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21579 (Residues: 141-268; Coverage: 30%)
Gene names: SVP65, SYT, SYT1
Sequence domains: C2 domain
Structure domains: C2 domain
Fibroblast growth factor 1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 133 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 23-155; Coverage: 86%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Protein S100-A13 Chain: C
Molecule details ›
Chain: C
Length: 98 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99584 (Residues: 1-98; Coverage: 100%)
Gene name: S100A13
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand
Protein S100-A13 Chain: D
Molecule details ›
Chain: D
Length: 98 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99584 (Residues: 1-98; Coverage: 100%)
Gene name: S100A13
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)