Function and Biology

Solution structure of ILK-PINCH complex

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF12796
Domain description: Ankyrin repeats (3 copies)
Occurring in:
  1. Integrin-linked protein kinase
The deposited structure of PDB entry 2kbx contains 2 copies of Pfam domain PF12796 (Ankyrin repeats (3 copies)) in Integrin-linked protein kinase. Showing 2 copies in chain A.

PF00412
Domain description: LIM domain
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
The deposited structure of PDB entry 2kbx contains 1 copy of Pfam domain PF00412 (LIM domain) in LIM and senescent cell antigen-like-containing domain protein 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002110
Domain description: Ankyrin repeat
Occurring in:
  1. Integrin-linked protein kinase
IPR001781
Domain description: Zinc finger, LIM-type
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
IPR036770
Domain description: Ankyrin repeat-containing domain superfamily
Occurring in:
  1. Integrin-linked protein kinase
IPR047944
Domain description: LIMS1/2-like, LIM domain 1
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
IPR017351
Domain description: LIM and senescent cell antigen-like-containing domain protein 1-4-like
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1

Structure domains

CATH CATH domains
2.10.110.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Cysteine Rich Protein
Homology: Cysteine Rich Protein
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
The deposited structure of PDB entry 2kbx contains 1 copy of CATH domain 2.10.110.10 (Cysteine Rich Protein) in LIM and senescent cell antigen-like-containing domain protein 1. Showing 1 copy in chain B.
1.25.40.20
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Ankyrin repeat-containing domain
Occurring in:
  1. Integrin-linked protein kinase
The deposited structure of PDB entry 2kbx contains 1 copy of CATH domain 1.25.40.20 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Integrin-linked protein kinase. Showing 1 copy in chain A.