PDBe 2kbr

Solution NMR

Solution structure of harmonin N terminal domain in complex with a internal peptide of cadherin23

Released:
Source organism: Homo sapiens
Primary publication:
Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.
Proc. Natl. Acad. Sci. U.S.A. 106 5575-80 (2009)
PMID: 19297620

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Harmonin Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 9.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6N9 (Residues: 1-80; Coverage: 15%)
Gene names: AIE75, USH1C
Structure domains: Paired amphipathic helix 2 (pah2 repeat)
Cadherin-23 Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H251 (Residues: 3183-3200; Coverage: 1%)
Gene names: CDH23, KIAA1774, KIAA1812, UNQ1894/PRO4340

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)